Provigil for depression

A Stanford University study showed that Provigil may be a “useful and a well-tolerated adjunctive agent to standard antidepressants in the treatment of major depression.” More recently a Vanderbuilt University study found that Provigil may have "general mood-elevating effects" and decrease feelings of anxiety. A University of Alabama study concludes "the use of modafinil for the treatment of residual fatigue is not recommended" although it recommend further study.

A 2007 report in the American Journal of Psychiatry found that Provigil had a response rate of 44% in patients with bipolar depression, and the authors state this rate is comparable to those in other studies. They call for larger studies to get firmer results.

A 2004 paper by S. Nasr published in the Annals of Clinical Psychiatry suggested that Provigil may prove useful as an adjunctive treatment in depressed patients. He found statistically significant improvements in mean Carroll Depression Rating Scale scores and Clinical Global Impression of Severity ratings amoung patients in his study

Some of the participants found that treatment with modafinil rapidly improved wakefulness, fatigue, and everyday functioning. The Provigil did not seem to negatively interact with antidepressants and other medications.

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A 2006 study at Duke University showed Provigl was effective in reducing the symptoms of atypical depression during 12 weeks of treatment.

Symptoms of depression of include energy loss, fatigue and anxiety. Provigil helps many people with those problems. Some doctors and patients have found, anecdotely, that Provigil alone can effectively treat depression, although it is more common for depressed people under treatment to take a conventional antidepressant along with the Provigil.

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SSRI antidepressants include Lexapro, Paxil, Celexa, Zoloft, and Prozac. For some people, these drugs don’t work, so doctors are always looking for alternatives. For others, they do work, but they have side effects.

Provigil has established a place in treatment of depression, and both clinical studies have proven its efficacy and practitioners have seen real results in patients.

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ProviglWeb does not sell Provigil or any other medication. We are not a medical site and cannot answer specific medical questions about your condition. Prescription medications such as Provgil should be taken only under the care of a doctor. Consult your doctor for advice about your situation.

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